The Love in the Wild host told People that her romance with the Chicago Bear recently ended after several months.
"Brian and I have decided to turn our romance into an amazing friendship. I will continue to be the biggest cheerleader for him. Go, Bears," McCarthy said in a prepared statement.
Urlacher and McCarthy went public with their relationship in May, after meeting a few months earlier at an autism benefit.
McCarthy was previously married to director John Mallory Asher for six years. The couple have a 10-year-old son together.
She also dated Jim Carrey from 2005 to 2010.