The rapper, who recently released his album 5 (Murder by Numbers) as a free digital download, told In Touch Weekly that he finds it difficult to commit to romances.
"I haven't been able to equally invest emotionally," he said. "I f**k everything up."
50 Cent also suggested that he is trapped in a pattern with his relationships, saying: "We go from being friends to being someone that you felt like you wanted to be with forever to not being friends at all."
50 Cent recently mocked Kanye West for his relationship with Kim Kardashian, saying: "One man's trash is another man's treasure."
He has said that he would be interested in collaborating with stars such as Tulisa Contostavlos and Frank Ocean.
Watch Digital Spy's recent chat with 50 Cent below: