The Who's the Boss? actor revealed his political aspirations at the premiere of Joseph Gordon-Levitt's new film Premium Rush on Thursday (August 23).
"I'm of a certain age, and you see things, and you think maybe you could help. You say, 'Let me fix the city. Let me run for mayor'," Danza said, according to The Wall Street Journal.
Danza - who declined to reveal his political affiliation - went on to reveal that he has serious interest in changing New York City's mass transit policies.
"We need less cars," he said. "I support the bike-share programme. And rollerblades - I'm a skater. You can't even take a cab from 50th to 70th street now. If it was up to me, I'd go for the congestion price."
The star concluded that his run is not set in stone, saying: "I'm concerned, I'm up-to-date, I read the papers. But could I stand the scrutiny?
"I'm not sure. It's a tough job. And it's not like anybody's asking me."
30 Rock star Alec Baldwin has previously hinted that he may run for New York City mayor "in the not-too-distant future" as well.