The couple exchanged marital vows at Wainwright's family home in Montauk, NY on Thursday (August 23), reports Page Six.
Wainwright and Weisbrodt later invited family and friends to a separate reception at the nearby Clam Bar in Napeague.
Lou Reed and his wife Laurie Anderson, Yoko Ono, Julianne Moore, Mark Ronson and Star Wars actress Carrie Fisher were among the 250 guests in attendance.
Weisbrodt and Wainwright became engaged in November 2010, but only began making wedding plans when same sex unions were legalised in New York last year.
The couple are parents to a baby daughter, whose mother is Lorca Cohen.
Watch Rufus Wainwright and Ben Folds perform 'Careless Whisper' below: