The singer will perform her new single 'Under the Sun' and will be interviewed by Ross on the ITV1 show, reports The Sun.
"Everyone is talking about Cheryl's latest relationship, so to have her confirmed for next Saturday night is fantastic," said an ITV source.
Lord Andrew Lloyd Webber will also appear on the programme, which will air on Saturday, September 8.
Double Olympic gold medallist Mo Farah, model Rosie Huntington-Whiteley and Gareth Malone will appear on this week's show (Saturday, September 1), while Plan B will be performing.
Cole will reportedly be joined by will.i.am and Wretch 32 during her arena tour, which begins in October.
Watch the video for Cheryl Cole's 'Under the Sun' below: