The actor has written to a New York government official in the hope that they will enforce a ban on carriage horses being used in the city.
The Pianist star was shaken by an accident that happened in New York last month.
A black and white carriage horse named Oreo ran through Midtown Manhattan and collided with a car, knocking two tourists and his driver out of the carriage and onto the street.
The driver suffered a broken leg from the incident that was provoked by the horse being spooked.
Activists believe horses do not belong on the city's chaotic streets.
Brody wrote a letter to City Council Speaker Christine Quinn People for the Ethical Treatment of Animals.
He said: "A horse and carriage belong on a deserted country road or in a small village, not in a big city filled with blaring noise, throngs of people, air pollution and fleets of taxis - where accidents are inevitable."
Brody is not the only famous face fighting for an end to the use of this transport. Glee star Lea Michele, singer Pink and actress Kathy Najimy have also made their feelings clear about the subject.