The brand picked up the 'Retailer of the Year' gong for the second year running and also won the 'Best Everyday Wear', 'Best Workwear' and 'Best Ad Campaign' categories.
Prima editor Maire Fahey said: "Congratulations to Next for again winning retailer of the year.
"In such a competitive high street market it is a fantastic achievement to dominate our awards for the second year running."
She added: "We're delighted the Comfort Prima High Street Fashion Awards 2012 is celebrating its 18th year and watching it evolve from a gathering of 30 people to a packed house of 1,200 proves it really is the ultimate girls' night out."
Comfort brand manager Mairead Greensmith said: "Comfort has been sponsoring the Prima High Street Fashion Awards for the last 9 years and we are privileged to continue our sponsorship again in 2012.
"The evening is a fabulous occasion to recognise the best of the British High Street and also have a sneak preview of upcoming fashion trends for next season."
Prima High Street Fashion Awards - photo gallery:
The complete list of winners at the Comfort Prima High Street Fashion Awards 2012 is as follows:
Best Accessories - Accessorize
Best Beachwear - Primark
Best Customer Service - M&S
Best Everyday Wear - Next
Best Department Store - John Lewis
Best Jeans - New Look
Best Jewellery - Accessorize
Best Lingerie - M&S
Best Occasion Wear - Debenhams
Best Online Retailer - John Lewis
Best 16 Plus - Evans
Best Shoes - New Look
Best Supermarket Range - George at Asda
Best Value for Money - Primark
Best Workwear - Next
Best Ad Campaign - Next
Best Celebrity Collaboration - Very.co.uk
Judges Award - Pepperberry
Best Social Media - New Look
Prima High Street Retailer of the Year - Next