The comedian, who split from Perry in December 2011 following a 14-month marriage, told Australia's 60 Minutes that marrying in less than a year had highlighted their differences.
He explained: "Sometimes it goes well, sometimes it don't. But if you sort of sense there's an incompatibility, then in any relationship regardless of the status of the individual, it kind of is best to go separate ways."
Brand continued: "I think if you're someone who's really into mountain biking, it would be good to go out with someone else who's into mountain biking, and if you're really into Eastern mysticism, go out with someone else who into Eastern mysticism.
"I think if you're a devoted tennis professional and you get married to a crystal meth addict, you might have trouble. I've been in a lot of trouble."
Since parting ways with Perry, Brand has been connected to a number of women, including Isabella Brewster and Geri Halliwell.
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