Staten Island Borough President James Molinaro made the remarks at the launch of an anti-substance abuse initiative following GaGa's controversial decision to smoke cannabis on stage, the Staten Island Advance reports.
"Stop glorifying the drug use," he said. "There's GaGa. Here's this... this... I would call her a sl*t. This sl*t is influencing many, many children.
"My niece has two daughters, 12 and 14, [and] they love this woman. Why? Why?"
Molinaro added: "We have a job to do also with these actresses, actors, ballplayers. They use drugs as if it's nothing. We shouldn't praise them. We shouldn't honour them. We should really hit them. We should hit the sponsors that she has... where her millions of dollars come [from].
"To me, she's not an actress, she's a sl*t... in the pure meaning of the word."
Molinaro later defended his use of the term in an interview with the New York Times, saying: "Looking up the word 'sl*t' to see if it was properly used before I used it, it said 'improper conduct'.
"Now, isn't it improper for someone who is so high profile to be smoking reefer in front of children? I have grandnieces that idolise her - 12 and 13 years old - and it's ridiculous. You see these young girls walking around on Halloween with her outfit on."
GaGa recently criticised the Pope after he spoke out against same-sex marriage.
Watch Lady GaGa smoke cannabis at her Amsterdam show below: