The stand-up, columnist for The Sun and author of My S**t Life So Far and Work! Consume! Die! is releasing his farewell disc next month.
"Bringing his sharp one-liners and excoriating wit to the stage for one last time, Frankie's vicious tongue takes no prisoners in this exhilarating farewell show," read the press release for the set.
"Frankie Boyle has been pilloried, misrepresented and demonised. And for what? For Telling It Like It Is."
The Last Days of Sodom is released on November 19.
Boyle this week won over £50,000 in libel damages from The Mirror after it called him racist and claimed that he was forced to quit Mock the Week.
The comic later said on Twitter: "I'm very happy with the jury's decision and their unanimous rejection of the Mirror's allegation that I am a racist.
"Racism is still a very serious problem in society which is why I've made a point of always being anti-racist in my life and work and that's why I brought this action."
He added: "I am giving my damages to charity."
Watch a trailer for Frankie Boyle's Tramadol Nights below: