The comedian has toured the set in Australia and New Zealand and will bring it to London for one night only at the Hammersmith Apollo on Tuesday, December 18 from 8pm.
"Bill Bailey had doubts about the modern world, but these have now grown into qualms," the press release reads.
"He will be channeling these feelings of unease and apprehension with the help of religious dubstep, his folk bouzouki, horntallica, a re-appraisal of some of the world's greatest works of art and perhaps a dub version of Downton Abbey."
It continues: "He looks at the consequences of lies, the unending search for the higgs and the hiding skills of dentists.
"Bill tries to confront his cluster-qualm of living in a time of spectacular ignorance and rare planetary alignment. Come savour this broth of anxiety with Bill Bailey, Qualmpeddler."
Tickets go on sale this Friday, October 26 at 9am and are priced at £25.
Watch Bill Bailey with Deep Purple below: