The Rise of the Planet of the Apes actor was reported to have flirted with Kristen Stewart at a Soho House party for the Toronto International Film Festival in September and has also been linked to Spring Breakers co-star Ashley Benson.
Franco poked fun at the romance rumours in his latest Huffington Post column, even joking about dating his fellow Spring Breakers castmemeber Selena Gomez.
"I also hear that I've been dating Selena Gomez, Kristen Stewart and Ashley Benson. Hot damn, am I a lucky guy," he quipped.
The actor continued: "I wish I had actually gotten closer than the 13th row of the theatre in Toronto where Kristen gave her On the Road Q and A, but I didn't; not only did I not talk to her, I didn't even go to the Soho House where I supposedly asked her out on a date.
"As for Gomez and Benson, those are Bieber's girls and I wouldn't dare tangle with the Biebs. I heard he wants to kick my ass. Yikes!"
Franco has famously dated his Whatever It Takes co-star Marla Sokoloff and actress Ahna O'Reilly.
He will next appear with Mila Kunis and Rachel Weisz in Oz: The Great and Powerful, opening on March 8, 2013 in the US and the UK.
Watch a trailer for Oz: The Great and Powerful below: