Reed, a former member of R&B trio Blaque, was killed in a road traffic accident on Friday evening (October 26), it was confirmed.
A press release from police in Gwinnett, Georgia said that they had received a call reporting that a pedestrian had been hit by a vehicle.
"The driver of the vehicle contacted 911 to request assistance," the release continued. "Natina Reed was pronounced dead at Gwinnett Medical Centre at 10.59 pm ET."
Police also confirmed that while the investigation into Reed's death is ongoing, there are currently no charges pending.
Blaque's Brandi Williams and Shamari Fears-DeVoe said in a joint statement: "We are devastated by the loss of our group member, sister and friend Natina Reed. Because of the enormous support of Blaque fans and our love for each another, Blaque officially reunited this fall and we were in the process of working on a new album and a reality show.
"Natina continuously embodied the pioneering spirit of Blaque and her undeniable creativity touched the hearts of fans everywhere. Natina was a mother, sister, accomplished songwriter, artist and friend.
"We ask for your prayers at this time for Natina's family. She will forever be missed and her global influence eternally felt. We thank God for the experiences we shared."
Reed also appeared in the films Honey and Bring it On, and was also believed to be working on new solo material in addition to the reunion with Blaque.
She would have marked her 33rd birthday tomorrow (Sunday, October 28).
Reed is survived by Tren Brown, her 10-year-old son with ex-boyfriend Kurupt.
Watch the video to Blaque's track 'I'm Good' from the film Honey below: