The 25-year-old rapper dropped out of school 10 years ago, and only received his high school diploma earlier this month.
Drake paid tribute to his mother in a speech at Jarvis Collegiate Institute in Toronto, saying: "I can honestly say that this piece of paper, I'd like to dedicate to my mother, because she's a retired teacher and always wanted me to graduate.
"I think I'll sleep a little better tonight knowing that I found a way to follow through."
Drake was just one credit short of graduating at the age of 15 when he left education to pursue a role on Canadian teen drama series Degrassi: The Next Generation.
He also gave some advice to his fellow graduating class, and revealed how happy he was to have finally completed his diploma.
"It's not necessarily about the books that you'll read or the science or math equations that you'll do, because you may end up taking a path in life where a lot of the things that you'll learn you can't necessarily fully apply," he said. "What this is about today, for all of you, is about the art of following through.
"I reached a point in my life where I saw that there aren't material things that can give me the excitement that I'm looking for. There's a void, a gap in my life that I needed to fill. It was the fact that I had left a gaping hole in my story following through."
Watch a video of Drake's graduation speech below: