The 'Superstorm' blasted New York, New Jersey and other coastal states on Monday (October 29), killing over 70 and flooding many highly populated areas.
GaGa - who was born and raised in New York - wrote an open letter in response to Hurricane Sandy, wherein she relayed feelings of heartbreak for those who have lost their homes.
"I'm not sure where to put these feelings. I'm so sad. I feel like my entire childhood is underwater. The boardwalk in Atlantic City [in New Jersey], my old apts [apartments] in Brooklyn and LES [Lower East Side]. All the bars and friends," she wrote.
She continued: "I'm just so sad. I know it will be OK. I'm not sure why I feel this way. Maybe homesickness, or maybe it's easier to be a gypsy if you know your soul grows from somewhere great.
"And that great place protected me my whole life, now parts are destroyed. Just very sad and pensive today. Thinking of everyone today."
The cast of Jersey Shore also spoke out about the tragedy this week, with Nicole 'Snooki' Polizzi sending well-wishes to all those who lost homes in Seaside Heights, NJ.
"Sandy destroyed Seaside - our second home. It's devastating to see our boardwalk and favourite spots ruined. My prayers go out to everyone affected by the storm," Snooki wrote in a press statement.
Relief and rescue efforts along the East Coast are ongoing as authorities attempt to find those who went missing in the storm.
NBC announced today (November 1) that it will air fundraising telethon Hurricane Sandy: Coming Together on Friday night (November 2).