Walters will profile ten public figures who made an impact on culture in 2012 in her annual television special, which airs on ABC in December.
The first seven of the '10 Most Fascinating People' have been unveiled by ABC, with the remaining three to be surprise revelations during the telecast.
Fifty Shades of Grey author EL James, Olympian Gabby Douglas and Argo director Ben Affleck are on the list along with One Direction and 2013 Oscars host MacFarlane.
Politicians among the '10 Most Fascinating People' include Secretary of State Hillary Clinton and New Jersey Governor Chris Christie.
Walters began her '10 Most Fascinating' list in 1993 and has since profiled celebrities including Clint Eastwood, Barbra Streisand, Christopher Reeve, Beyoncé, Kanye West and Katy Perry.
Barbara Walters Presents: The 10 Most Fascinating People of 2012 airs on December 12 at 9.30/8.30c on ABC.
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