The couple's marriage has been the subject of speculation over the last several months due to Kimberly filing for divorce in March.
She later withdrew those divorce documents, only to file for legal separation in mid-October.
Dennis took the next legal step to dissolve his marriage by officially filing for divorce in Los Angeles on Friday (November 30), reports ET Online.
The actor cited "irreconcilable differences" as the cause of the split and is also seeking joint legal and physical custody of the couple's children.
This was the third marriage for Dennis, who was previously married to PJ Soles from 1978 to 1983 and Meg Ryan from 1991 to 2001.