The 29-year-old Straw Dogs actress is directed by fiancé Michael Polish in the cinematic production inspired by The Fabulous Baker Boys, which sees the sultry star sing on top of a piano.
Bosworth wears a chic custom-made evening dress in the campaign, which will be available as a special made to order on topshop.com in conjunction with their new store opening in LA in February 2013.
Speaking about her partnership with the high street fashion store, Bosworth said: "This project brings together two important aspects of my life: cinema and fashion. I have always been a fan of the brand and it has been an honour to work with Sir Philip and the team.
"I hope everyone enjoys watching it as much as we did making it."
Creative director Kate Phelan added: "I think Kate looks effortlessly cool in this film, her voice is spellbinding."
Topshop are hoping for a Christmas No.1 with Bosworth's 'Winter Wonderland', which is available to download through iTunes.