The term 'Rita Whora' trended worldwide on Twitter on Monday (December 3) after Kardashian posted a series of now-deleted scathing messages about a recent break-up.
Kardashian - who had been romantically linked to Ora - wrote: "She cheated on me with nearly 20 dudes while we were together, I wonder how many she will sleep with now that we apart? But I mean 20?!!!
"How can a woman who is so busy trying to start her own career have time to be with so many dudes all while in a relationship?!"
Kardashian later claimed that that his ex-girlfriend had "let [him] get [her] pregnant", but later removed that post as well.
The Keeping Up with the Kardashians star has since returned to Twitter to criticise the media for assuming he was writing about Ora.
"Just so we clear I never once mentioned 'Rita Ora' in any of my tweets or even used the word 'wh*re' and I never would. I Respect Women," Kardashian insisted.
He continued: "Sad that the media created negativity for a young artist new to the game that is working so hard to make it. Never mentioned any names.
"I speak truth. I'm a very Real dude and everything I say I mean... But never called anyone specific a wh*re and said any names. You all did."
Kardashian and Ora were rumoured to have ended their romance over the weekend due to their busy schedules.