According to reports, Cruise has been persuaded by his good friend David Beckham to go see the match.
[Cruise in new film Jack Reacher]
The Mission: Impossible actor is currently filming All You Need Is Kill in Hertfordshire, but has got his crew arranging transport so he can travel the 200 miles to City's Etihad Stadium.
A source said: "Tom's filming on Saturday, the match is a lunchtime kick-off and he has to be in London for the premiere of his film Jack Reacher on Monday.
"We've been working out whether to get a jet or helicopter or go by road. Tom's on a very tight schedule, but is desperate to see the match.
"Becks told him, 'If there's one game you see, this is it'. So he's been buzzing to get up to Manchester.
"He won't be shouting for United or City. He'll be there as a fan of sport. The only thing that may put a spanner in the works is if filming over-runs."
Jack Reacher will be released on December 21 in the US, and December 26 in the UK.
Watch a new clip from the action movie below: