The 10-year-old son of David and Victoria Beckham will star in the new campaign for the label's Spring/Summer 2013 collection.
Romeo was shot alongside Edie Campbell and Charlie France by renowned fashion photographer Mario Testino for the promo video.
Burberry's creative director Christopher Bailey said: "We had such fun shooting the campaign and I think that comes through in the images."
A source told Grazia that Romeo was "a joy to work with and really stole the show".
David Beckham previously admitted that his son has always been fashion-conscious, revealing: "Brooklyn will just wear his soccer shirts and T-shirts, but Romeo is the fashion one, so he'll go for skinny jeans and a vintage T-shirt and funny hats. One Christmas he asked for a pair of Spats shoes."
Romeo recently attended the opening night of Spice Girls musical Viva Forever! with his parents and brothers Brooklyn and Cruz.
The family are currently staying in the UK for Christmas, amidst rumours that they are planning a permanent return to the UK.