Entitled 'Demand A Plan', the black and white video stars actors and singers, comedians and sport stars encouraging Americans to approach government leaders with the request to draw up new laws surrounding gun possession.
The famous faces take it in turns to ask the viewer "How many more?" before naming buildings and sites that have played host to gun tragedies in recent years.
They then go on to urge the audience to take action now as a mum, dad, American and simply as a human being to prevent their loved ones ending up on a list of fatalities as shootings continue to occur.
Featuring Beyoncé, Ellen DeGeneres, Steve Carell, Jennifer Aniston, Paul Rudd, Jamie Foxx and many others, the powerful campaign aims to "pass gun laws that require background checks for every gun sold in America, ban assault weapons and high-capacity magazines, and make gun trafficking a federal crime".