The Real Time comic will be appearing semi-regularly at the Palms resort and casino's Pearl Theater throughout 2013, organisers announced this week.
Maher will begin the residency on March 23-24, prior to taking a break for several months.
He will return to the venue on June 8-9, September 6-7 and November 2-3.
Tickets will go on-sale for the first two shows from January 10 via Ticketmaster.
The comedian will continue hosting his HBO series Real Time throughout this period.
Real Time with Bill Maher airs on Fridays on HBO.