The This Morning presenter designed her tenth range for the fashion store, which she revealed was mainly aimed at curvy women.
Willoughby posed for a photoshoot to show her new range, including a classic Hollywood-style red dress.
"I love getting dressed up," she said. "I think that every woman deserves a bit of glamour in her life."
Another photo sees the TV presenter in a beige dress, while another displays a retro-style turquoise dress.
"Holly designs with curvy women in mind," said Julie Donnelly, head of womenswear buying at Very.
"She knows what works for her and brings this experience into her designs."
The range is now available to purchase from the Very website.
Holly Willoughby was named the 'world's most desirable woman' in a poll by AskMen in December.
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