The filmmaker was due to host a special SMorgy Podcast show at the Spatz Theatre in Halifax, Canada on January 26.
However, he has now axed the plans because his 13-year-old daughter Harley has reached the finals of a 'battle of the bands' competition.
Smith explained that he wanted to be able to see his daughter perform, and hoped other parents would understand his decision.
He jokingly compared the situation to his 2004 movie Jersey Girl, which starred Ben Affleck as a single parent.
"It is with a heavy heart that I announce the cancelling of this weekend's SMorgy event," he wrote on Facebook. "The blame for this lies solely with me... Saturday's cancellation is a bit of Jersey Girl coming back to haunt me.
[Ben Affleck in 2004's Jersey Girl]
"My daughter Harley entered a battle of the bands last week and has moved on to the finals. The show is this weekend - same time as SMorgy.
"Had I not been the guy who made Ben Affleck's character give up a great job opportunity just to see his daughter's school play, I wouldn't be making this call.
"But she's 13 years old, she's never played before a crowd this large, and I've only got one kid: if I miss this moment to tell d**k jokes with friends half a world away, I'm a bigger asshole than if I cancel the event. So stuck between and rock and a hard place, I apologise - I gotta do the dad thing here."
Kevin Smith will appear as a guest judge alongside longtime collaborator Jason Mewes on TBS reality show King of the Nerds, which launched on January 17.