The X Factor star has joined the cast of TV show Good Luck Charlie and Jessie to back the collaboration from Disney UK Childnet and the Child Exploitation and Online Protection Centre (CEOP).
"Having only recently left school myself, I know how important it is that kids get plenty of help and guidance as they grow up," Henderson said.
"Whether it's on or offline, friendships can be tricky and sometimes it's hard to know where to go for help.
"It's great that Disney, Childnet and CEOP are working together to make sure kids know the help that's out there and the basic rules of behaviour online."
CEO of Childnet and director at the UK Safer Internet Centre Will Gardner added: "Children need to know how to connect with respect and that being a good friend online is really no different to being a good friend in the real world.
"Childnet is delighted to partner with Disney in order to communicate this message to a bigger audience, and we've collaborated to create compelling, relevant content which ties in to Safer Internet Day."
The campaign will run across Disney's network of channels, websites and stores in the lead up to this year's Safer Internet Day on February 5 with the theme of 'Connect with Respect'.
As part of the campaign, players of Disney's virtual world Club Penguin can complete a safety quiz and download a virtual item for their penguin to show their commitment to safety.
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