Despite the downpour and freezing cold weather, Van Outen, 38, wore a sleeveless black gown with a sheer lace panel at the front and back while Harding, 31, donned a shimmering, silver dress with a similar plunging neckline lace panel.
Former EastEnders actress and co-star Kellie Shirley wore a grecian-style frock which got drenched at the bottom from the soggy red carpet, while Dyer kept it casual and simple in a pair of jeans and a blazer.
Other guests at the screening included co-stars Neil Morrissey and Lionel Blair, Denise Welch and toyboy Lincoln Townley, Aisleyne Horgan-Wallace, Su Pollard and Liz McClarnon.
TOWIE's Lydia Bright and former TOWIE star Kirk Norcross, David Jason, Anna Williamson and John Altman were also in attendance.
Run For Your Wife, written and co-directed by Ray Cooney based on his own stage play, will open in UK cinemas on February 14.
See all the stars at the Run For Your Wife premiere here: