A picture of the 43-year-old record producer and 'Empire State of Mind' rapper was posted on the She's the Manstar's account alongside the caption.
The tweet was swiftly removed, but no explanation was offered for the comment. It is still unclear if she sent the tweet or if her account was hacked.
She also deleted other posts on the social networking site, leaving only 17 tweets in total on her page.
On Monday (February 4) it was reported that Bynes had moved out of her apartment in New York to avoid an eviction. She was apparently due to be told to leave the property after being labelled a "nuisance".
It was claimed this week that Jay-Z refused to appear during wife Beyoncé's Super Bowl half-time performance on Sunday (February 3) since it was "her moment".
Watch the video for Jay-Z's '99 Problems' below: