Mitch Winehouse criticised the lack of funds given to covering drug and alcohol related issues on the curriculum, warning that the prevalence of legal highs needs to be addressed.
The Amy Winehouse Foundation Resilience Programme will be launched in 50 secondary schools across England, aiming to ensure that both teachers and young people are better informed.
"Everyone wants their kids to make informed choices when it comes to drugs and alcohol," Mitch said.
"But it's such a complicated subject to understand, especially when you look at all the new legal highs that have appeared over the past few years, that it's no wonder that parents feel in the dark about what to do.
"Drugs education in schools is woefully underfunded and has been far too inconsistent. That's if it happens at all. When it does, it doesn't look at why people turn to drugs or drink.
"Our new secondary schools programme will give everyone - including parents, teachers and the pupils themselves - the skills and knowledge they need. That's something that will really help our young people."
Russell Brand will help launch the initiative, which also provides a free, confidential phone and online service for young people, supported by ChildLine.
The comedian is due to attend the launch of the programme, developed in conjunction with Addaction, at the Queen Elizabeth II Conference Centre in London on Tuesday.
Amy died in July 2011 from accidental alcohol poisoning at the age of 27 after a long battle with drink and drugs.