The British royal paid tribute to young people who have battled their issues to achieve success, with help from his charity.
Ant & Dec were among the stars at last night's event, with Prince Charles giving a nod to their surprise potential number one success with 'Let's Get Ready to Rhumble'.
"They seem to have discovered the secret of eternal youth. I suspect it must be all that rhumbling they do," he joked.
"Anyway, I hope they keep rhumbling on."
Homeland actor Damian Lewis, The Wire's Idris Elba, Mark Ronson and Dame Helen Mirren were also in attendance at London's Leicester Square Odeon.
Prince Charles also referenced Mirren's current theatre role as the Queen in The Audience, saying: "I have a feeling that Dame Helen Mirren should really be putting on a familiar wig in some West End theatre now."
Speaking about his charity and annual awards, he said: "Each time it makes me feel prouder and prouder."
Mirren said of the evening: "All the young people here today are truly inspirational. Their remarkable stories have blown me away."
Damian Lewis presented the 'young achiever of the year' award to Afsana Benozir, who received a hug from Prince Charles. She previously self-harmed and attempted suicide after being abused at a young age by a family friend. However, she now plans to study medicine next year.
Lewis said: "Afsana's story is truly remarkable. I'm honoured to have met her."
The Prince's Trust Awards: Red carpet pictures