The rapper was taken to Cedars-Sinai hospital in Los Angeles yesterday evening by his bodyguards, after having a single seizure, reports TMZ.
He was treated by doctors before being released early this morning (May 1).
The 'Drop the World' star was hospitalised in LA last month after suffering several seizures, forcing him to spend days in intensive care.
He later thanked his fans for their ongoing support, stating that he was "more than good".
Lil Wayne recently admitted that he has been battling seizures since he was a child.
He said: "The bad news is I'm an epileptic, I'm prone to seizures. Like, this isn't my first, second, third, fourth, fifth, sixth, seventh seizure. I've had a bunch of seizures, y'all just never hear about them."
Watch Lil Wayne and Eminem's 'Drop the World' music video below (Note: adult content):