The stand-up star claimed he admired Brand's humour, but argued that his wild lifestyle gave off the wrong signals for aspiring entertainers.
Lock told The Scotsman: "Whenever a young comic asks me for advice I only have two things to say. One is to try and do what you think is genuinely funny and the other is just do loads of gigs.
"Russell is a funny bloke and a talented man but I think he is a bad example to young comics in that to try to achieve success you have to disembowel yourself for public consumption, with every single detail of your life being sold and bartered for attention."
Brand is currently working on a movie adaptation of his best-selling autobiography My Booky Wook.