The 28-year-old actor, who plays cross dresser Kris Fisher in the Chester-based soap, will return home to Belfast for the one-off Lyric Theatre performance later this month.
Writer David Johnston's new adaptation of the French playwright's classic will be the headline show during the theatre's 'off-site' season while its new £18 million home is built in the city.
McCarthy has previously performed alongside Liam Neeson and James Nesbitt for the last ever performance at The Lyric's old site.
Speaking today, he revealed: "I am delighted to be back at The Lyric. Molière is a world away from Hollyoaks and I'm really looking forward to getting my teeth stuck into this French classic, directed by Dan Gordon."
The Miser is a comedy of manners focusing on a rich moneylender Harpagon and the love lives of his children.
McCarthy can be seen in the show on October 23 at Belfast's Elmwood Hall. Tickets are already on sale.