The 28-year-old, best known for his soap role as Kris Fisher, will fly home to Northern Ireland this weekend in order to support the Belfast4Haiti event, which takes place on Sunday.
Discussing his reasons for participating in the fundraising effort, McCarthy explained: "Haiti is the poorest country in the western world and has been victim to a host of natural disasters in the past. However, the earthquake that hit on 12th of January has not only left more than 100,000 dead but has, in its wake, left tens of thousands of people in imminent danger due to the shortage of food, water, shelter and medical supplies which are so desperately needed in order to prevent more death.
"This is the biggest humanitarian aid relief programme since the Tsunami and even though we are in difficult economic times, once again the international community has shown that when disaster strikes we will step up to the mark to help those who are most vulnerable and in need."
He added: "I am asking the people of Northern Ireland to come out and support Belfast4Haiti on Sunday to raise much needed funds for a country destroyed and to help save lives. Everyone has their part to play - no-one can do everything, but everyone can do something."
Former Olympic pentathlete Dame Mary Peters has also agreed to take part in the run.
Click here to read more about the Belfast4Haiti event.