The Queens Park Rangers footballer repeatedly described the ITV2 stars as "lemmings" and "helmets" after seeing them at the launch of Call of Duty: Modern Warfare 3 last night.
Barton tweeted at the event: "Just for the record the TOWIE helmets were there, all of them together. FREAKS."
"Off to bed, keep me updated people with the TOWIE blerts, all thats wrong with the world that mob, I'll take great pleasure in abusing them.
"I actually despise the whole of that firm, mentally deficient, turn up at the opening of an envelope, fame hungry, prized ball bags. #TOWIE"
The 29-year-old had kinder words for Kirk Norwood, adding: "The only one whose alright is Kirk?? He's like my favourite. When I say favourite, its like if u had to pick a sexually transmitted disease!"