The actress - who played Heather Trott in BBC soap EastEnders - will appear as the Fairy Godmother in the Central Theatre's panto Cinderella later this year.
Pantomime producers Evolution Productions approached her to star in her first ever panto role in Chatham, Kent, reports Kent News.
She said: "I'm thrilled to be playing the part of the Fairy Godmother in Cinderella, and I've heard that the Central Theatre and Medway audiences are brilliant, so it's going to be loads of fun."
Pantomime producer Paul Hendy added: "We're really proud and excited that Cheryl will be headlining our cast. She's such a great character both on screen and off, and is hugely popular with viewers of all ages, so we know she's going to go down a storm in Chatham this Christmas."
Cinderella will run at the theatre from December 13 to January 6.
EastEnders fans saw Fergison's last appearance as Heather on March 19 when she was killed by teenager Ben Mitchell.
Fergison recently said that she is interested in pursuing a music career.
> Cheryl Fergison on soap exit: 'There were lots of tears'