The actor has filed paperwork to legally separate from Catherine McClenahan in Los Angeles after 23 years of marriage, according to TMZ.
Fagerbakke apparently cited "irreconcilable differences" as the cause of the separation in court documents.
The couple apparently began living separately last year, but only made the break-up official last week.
Fagerbakke plays Marshall's father Erik on How I Met Your Mother and also voices Patrick Star on Spongebob Squarepants.
He also famously played Dauber on Coach in the 1990s.