Cena filed the documents in Florida, claiming his marriage to Liz Huberdeau is "irretrievably broken", TMZ reports.
Cena and Huberdeau - who have no children - have been dating since attending high school together. However, they only married three years ago.
Huberdeau has hired Raymond Rafool, a Miami-based attorney who also represented Linda Hogan during her divorce from Hulk Hogan.
Her legal team have said that the filing came as a total surprise to her and although the couple had been having problems, Huberdeau declined a pre-divorce financial agreement suggested by Cena in the hope that they could work out their issues.
Huberdeau is believed to have signed a pre-nuptial agreement prior to the marriage in 2009.
Her lawyer said in a statement: "Although it is indeed unfortunate that John Cena decided to divorce his high school sweetheart Liz Cena - particularly after they have come so far in their lives and in his career together - Liz will and really has no choice but to pursue all of her rights and entitlements.
"Sadly, divorce is not the way Liz thought her perfect love story would end."