The actress, who decided to leave the street after 14 years to pursue other acting projects, will play the Wicked Queen from Friday December 2 to Monday January 2 at Blackpool Grand Theatre.
Coronation Street producer Phil Collinson said of her leaving: "Vicky created a strong and uncompromising battleaxe with a heart of gold lurking underneath - in the true tradition of great Coronation Street women. She'll be missed by us all and we wish her well."
Entwistle will star alongside Steve Royle from BBC Radio Lancashire in the classic fairytale fantasy.
The rest of the all-star supporting cast is yet to be announced.