The actor, who plays Kevin Webster in Coronation Street, is accused of 19 offences including raping a child, indecently assaulting a child and sexual activity with a child.
Greater Manchester Police confirmed that the reported offences are said to have taken place between 2001 and 2010.
The 48-year-old, who has been charged under his real name Michael Turner, is scheduled to appear at Manchester Magistrates' Court on Wednesday, February 27.
Le Vell was arrested and questioned over the alleged child offences in September 2011, but he strenuously denied the claims and the matter was later dropped.
Alison Levitt QC, Principal Legal Advisor to the Director of Public Prosecutions, said on Thursday evening (February 14): "I have very carefully reviewed the evidence in this case and I have concluded that there is sufficient evidence and it is in the public interest to charge Michael Robert Turner with a number of sexual offences.
"As proceedings are now active, it would be inappropriate to say anything further at this stage."
The actor joined the long-running ITV soap in 1983 as the popular garage mechanic Kevin.