The Vampire Diaries actor and his wife, who also stars on the hit supernatural show, have decided to end their marriage after two years, according to People.
A representative for the 31-year-old actor said that they "have decided to amicably split. They will continue to remain good friends."
The pair met in 2007 on the set of the film Killer Movie and were married in New York City in 2011.
Wesley recently spoke of his excitement at playing Silas in the show's upcoming fifth season, after it was revealed that Stefan is his doppelganger.
Speaking at San Diego's Comic-Con, he said: "I love the challenge and I love that Stefan is in the bottom of a lake. I love him, but at the same time, I feel like I need a little space from Stefan right now."