Speaking to Parade, the Gossip Girl star explained that she's appreciative of having been given opportunities to play a wide variety of parts.
"I've been so happy with how everything has gone so far, and I'm ecstatic with the direction I'm headed at the moment," she said. "I've been really lucky to play different roles and that's what's important to me."
She added: "As exciting and thrilling as playing Rebecca was in The Roommate, I wouldn't do it again. Just like [my Gossip Girl character] Blair - I probably won't ever play a character like her again. And the same with Country Strong. I think doing something totally different is nice."
Aside from her acting endeavours, Meester's collaboration with Cobra Starship on 'Good Girls Go Bad' became a US top 10 hit in 2009 and she also recorded several songs for Country Strong's soundtrack.
Meester will star with Selena Gomez in Monte Carlo, which is released on July 1 in US cinemas and on August 12 in the UK.