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Speaking to DS, Knepper - who recently joined the cast of Heroes - admitted that when he announced to Sutherland that he may quit acting, the 24 star reacted by punching him.
He said: "10 or 15 years ago, Kiefer used to go to the same gym as me. I remember telling him that I wanted to quit. It was before Prison Break and I couldn't find any work and I wanted to quit.
"He f**king punched me! He punched me so hard. He told me, 'Don't you ever give up!' and I thank Kiefer every day for that advice."
Earlier this year, Sutherland was charged with assault after allegedly headbutting a fashion designer.
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