The veteran actor will face competition from ex-Home And Away stalwart Kate Ritchie, who hopes to make it three wins in a row.
Smith, whose final scenes as Harold Bishop screened in Australia in February, was the focus of a very public campaign by Neighbours to give him a golden sendoff. Celebrities including Tom Jones, Rick Astley and WWE wrestler John Cena urged fans to vote for Smith as part of the 'We Heart Harold' campaign.
Ritchie's nomination, her third, comes a year after she last appeared as Sally Fletcher.
Smith and Ritchie will go head-to-head with six other nominees: Natalie Bassingthwaighte (So You Think You Can Dance Australia), Andrew Denton (Enough Rope With Andrew Denton), Rebecca Gibney (Packed To The Rafters), Adam Hills (Spicks & Specks), Simmone Jade Mackinnon (McLeod's Daughters) and Rove McManus (Rove).
Home And Away received seven nominations, including most popular drama and two nominations for Ritchie (most popular personality on television [Gold Logie] and most popular actress). Jodi Gordon also received a nomination for most popular actress, while Todd Lasance picked up a nod for most popular actor.
Newcomers Rebecca Breeds and Jordan Rodrigues both received nominations for most popular new female talent and most popular new male talent respectively.
Neighbours managed to score five nods in total, with Ian Smith recognised in the most popular personality and most popular actor categories. Dean Geyer is up for most popular new male talent and Margot Robbie received a nod for most popular new female talent.
Neighbours is also in the running for the most popular Australian drama gong, alongside Home And Away, Packed To The Rafters, McLeod’s Daughters and Underbelly.
Drama series Packed To The Rafters led the pack with 11 nominations, closely followed by underworld crime series Underbelly with nine.
The 51st TV Week Logie Awards will air live in Australia on Sunday, May 3.