The Walford serial has racked up 19 out of the possible 52 nominations across the 13 eligible categories. Lacey Turner (Stacey Slater) is in the running to land the best actress award for the fourth year in a row but faces competition from co-star Patsy Palmer (Bianca Jackson).
Scott Maslen (Jack Branning) and Larry Lamb (Archie Mitchell) hope to take home the best actor and best bad boy award respectively.
Ex-Ender Lauren Crace - who played the show's now-dead Dannielle Jones - could win her second best newcomer award in a month, despite having disappeared from screens in April.
Meanwhile, ITV soap Coronation Street has 17, including Helen Flanagan's (Rosie Webster) nomination for best bitch and the Barlows's nod for best family.
Katherine Kelly (Becky McDonald) hopes to score another best actress award, while Gray O'Brien could walk away from the ceremony as this year's best bad boy for his portrayal as murderous entrepreneur Tony Gordon.
Hollyoaks notched up 10 nominations, with former screen lovers Chris Fountain (Justin Burton) and Emma Rigby (Hannah Ashworth) in the running for best actor and actress. Hollie-Jay Bowes (Michaela McQueen) could receive the gong for funniest performance.
Emmerdale secured the lowest number of shortlisted nominations with six in total, including Jeff Hordley (Cain Dingle) and Nicola Wheeler (Nicola De Souza) for bad boy and bitch and Sammy Winward (Katie Sugden) for sexiest female.
All four main UK soaps along with Neighbours and Home and Away are in the running for best soap, while The Bill, Casualty, Holby City and Doctors are nominated for best drama.
The 14th annual Inside Soap Awards take place on Monday at Sketch in London's West End.