The actress's character - the ambitious clinical matron, Louise Fox - is to be tempted by another job outside of Holby General.
A spokeswoman told DS: "The character of Lisa has been wonderful in the show and she has always had a huge sense of fun and adventure."
She added: "So in the months to come we will see her unable to resist the challenge of working in a setting very different to Holby City Hospital."
Luisa is still filming and her final scenes will be screened in September.
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