The hard-hitting soap opera, which was axed by Channel 4 in 2003, will be celebrated this coming Sunday (November 4) with special guests including creator Phil Redmond.
Claire Sweeney (Lindsey Corkhill), who recently claimed that Brookie should never have been cancelled, will also attend the all-day event, as well as her on-screen dad Dean Sullivan (Jimmy).
Finally, Brookside's most senior writer Peter Cox, who penned 227 episodes between 1986 and 2003, will join the lineup.
Redmond, who is now the chairman of National Museums Liverpool, has released a statement saying: "It's quite unbelievable that it's been 30 years since Brookside came to life on our screens and I am now old enough to be a museum exhibit!
"We always tried to make the programme as real as we could within its fictional setting and the outstanding quality owed a lot to the writers, actors, staff and crew who took that special magic that Liverpool provides and made a great programme.
"Dean, Claire and Peter were all long-standing contributors and there until the final episode, so it will be great to have this day and share an afternoon of reminiscence and nostalgia to mark what would have been its 30th anniversary."
Following a hard-fought, fan-led campaign, Channel 4 will be also releasing a DVD at the end of next month to tie in with the celebrations.
Watch the official trailer for the Brookside - Most Memorable Moments DVD below: