According to The Sun, a hard-hitting plot on the ITV1 soap will see Jackson ask Aaron (Danny Miller) and mum Hazel (Pauline Quirke) to help end his life following his recent struggle to cope with his paralysis.
It is thought that Aaron and Hazel will eventually comply with their loved one's request and crush lethal tablets into a drink for him.
Jackson - played by 22-year-old Marc Silcock - was left seriously injured in a train accident last year, which led to him losing the use of his limbs. Since then, he has found it difficult to adjust to the tragic change in his life - in particular being so reliant on other people.
A show source told the newspaper: "Jackson will start discussing plans to end his life in the next few weeks. His resolve to see it through will strengthen, which will lead to many rows and emotional scenes.
"Throughout the plot, there will be a phone number on screen for a helpline for anyone affected."
Responding to the report, an Emmerdale spokesperson told DS this morning: "We do not confirm or deny speculation about future storylines."
Jackson made his Emmerdale debut in March 2010 and his on-off relationship with Aaron has built up a devoted following among viewers. Next week, fans will see the pair reunite following their recent split.