The 25-year-old makes her comeback to the Channel 4 soap as Clare Devine to tie in with the departures of Chris Fountain (Justin Burton) and Jamie Lomas (Warren Fox).
An unstable Clare returns set on exacting revenge and quickly becomes involved in a blazing fire at The Loft nightclub.
Speaking of her return, she told PA: "It's exciting stuff to come back and play Clare. I don't think I've ever found a character like her - there's no limit as far as she's concerned."
She added: "In these episodes in particular, she's come back slightly unhinged and there isn't much that gets in her way and that's what I think is so exciting."
Bissix returned to filming earlier this month and reappears on screens during the final week of May.