The 25-year-old makes a brief comeback as the Channel 4 soap's super vixen Clare Devine during Stunt Week 2009, which begins on Monday.
Clare returns to the village in dramatic style and hell-bent on exacting revenge on Justin Burton (Chris Fountain) for pushing her off The Loft balcony in 2007.
Speaking of her decision to reprise the role, Bissix told DS: "The return came about at Christmas. I had a phone call from Bryan Kirkwood saying that he was doing his final episode and would I be involved, and that was it really! I was the first person Bryan employed and now the last person too!"
She continued: "I did it for my love of Hollyoaks. When Bryan asked me I rang my agent and said 'no matter what the fee is - whatever, just let me do it!' It was really lovely to go back and see everybody - just amazing."
The week of episodes - which are being billed as some of the programme's biggest of the year - and the events that follow result in the departures of three Hollyoaks favourites: Justin, Warren Fox (Jamie Lomas) and Russ Owen (Stuart Manning).
> Click here to read our recent interview with Gemma Bissix